Join the mission to realize the full potential of peptide modality

Our team brings together exceptional talent with a passion to explore uncharted territory and a laser focus on bringing new medicines to patients — with a sense of urgency.

Apply now Learn more

Life at Pinnacle Medicines

Grow your expertise on problems that matter.

At Pinnacle Medicines, you'll work closely with scientists across the full spectrum of drug discovery - from chemistry and biology to formulation and CMC.

We've deliberately built a culture without silos because breakthroughs often happen at the interfaces between disciplines. Program updates, data, and decisions are shared openly across the company, and everyone — regardless of seniority — is encouraged to contribute and push the science forward.

For early-career researchers, this means sitting at the table from day one with access to the raw data, candid conversations, and the experience of those who've successfully brought new medicines to patients.

Breakthrough science runs on rigor and curiosity in equal measure. At Pinnacle, both are valued.

Current Opportunities

Open positions

We are building a multidisciplinary team of scientists, engineers, and drug development experts advancing next-generation peptide therapeutics. Explore opportunities to contribute to our growing discovery and development programs.

Executive Director of Project Management Apply now

Lead cross-functional program strategy across Pinnacle's peptide discovery and development portfolio. Read more

location_onDoylestown, PA
timer_5Full time

About the Role

We are seeking a strategic and execution-focused Executive Director of Project Management to lead cross-functional program management across Pinnacle's peptide discovery and development portfolio. This individual will serve as a core member of the development leadership team and will be responsible for driving integrated program strategy, governance, timelines, and resource alignment from early discovery through IND-enabling activities and into early clinical development. The ideal candidate brings deep experience managing complex drug development programs in biotech environments and has demonstrated success aligning scientific, regulatory, CMC, and external partner functions to deliver milestone-driven outcomes. The position will be reporting to the Head of Translational Science.

Responsibilities

  • Lead and oversee cross-functional program management across discovery and development programs.
  • Partner with Research, DMPK, Bioanalytics, Toxicology, CMC, Regulatory, and Clinical teams to build and maintain integrated development plans.
  • Drive scenario planning, risk mitigation strategies, and milestone forecasting to support portfolio prioritization.
  • Establish and manage governance structures, including program reviews and executive updates.
  • Ensure alignment of timelines, budgets, and resources with corporate strategy.
  • Identify and proactively resolve program risks, bottlenecks, and cross-functional conflicts.
  • Lead external program oversight for CROs, CDMOs, and strategic collaborators as needed.
  • Develop scalable project management processes appropriate for a growing biotech organization.
  • Support due diligence activities and business development evaluations.

Qualifications

  • Requires a Ph.D. orM.S.in life sciences, or equivalent experience, with a minimum of 10 years of drug development program management experience in biotech or pharmaceutical environments.
  • Demonstrated success leading cross-functional teams through IND-enabling programs and early clinical development.
  • Strong understanding of nonclinical, CMC, regulatory, and early clinical development processes.
  • Experience implementing governance frameworks and portfolio management tools.
  • Exceptional communication, influence, and executive presentation skills.

Preferred Skills

  • Experience with peptide or macrocyclic drug development.
  • Experience building PM functions in early-stage biotech settings.
  • PMP certification or formal program management training preferred.
Director of DMPK Apply now

Lead pharmacokinetics and drug metabolism strategy across a growing peptide pipeline. Read more

location_onDoylestown, PA
timer_5Full time

About the Role

We are seeking a highly motivated and experienced Director of DMPK at our Doylestown, PA site. The candidate will work within the discovery team and be responsible for ADME/DMPK aspects of all of our peptide discovery and development pipeline, including lead identification/optimization, FIH translation, and non-clinical packages to support regulatory filings. The candidate must have demonstrated an ability to work collaboratively in a fast-paced, dynamic environment with excellent scientific and communication skills. The position will be reporting to the Head of Translational Science.

Responsibilities

  • Lead and manage ADME and DMPK functions, design and implement strategies for ADME and DMPK studies, interpret data and integrate it into overall project plans.
  • Design and execute mechanistic and translational studies to evaluate the pharmacokinetic and metabolic properties of macrocyclic peptides to influence design, lead selection, and drive PK/PD translation and human dose prediction.
  • Advance the use of modeling techniques to accelerate lead selection/optimization and the progression of clinical candidates with high probability of success.
  • Collaborate with internal and external partners to provide strategic DMPK guidance, and plan and execute DMPK studies to support preclinical and clinical drug development.
  • Manage DMPK budget and provide budget planning.
  • Provide DMPK expertise to project teams, ensure compliance with industry regulations and standards in all DMPK activities, and advise on the DMPK aspects of regulatory submissions and author regulatory documents from FIH through registrational filing.
  • Stay informed of external advancements of DMPK for peptide drug discovery and contribute to the evaluation and implementation of cutting-edge technologies and methodologies.
  • Participate in due diligence and business development activities as needed.

Qualifications

  • Requires Ph.D. in Pharmacokinetics, Pharmacology, Biochemistry, or a related discipline with minimum of 7 years of relevant DMPK experience in a biotechnology or pharmaceutical environment.
  • At least 3 years of management experience, including staff development and budget responsibility.
  • Demonstrated expertise and successful experiences of independently leading DMPK efforts in small molecule or peptide drug discovery teams within a fast-paced, dynamic and collaborative environment.
  • Capable of analyzing and interpreting complex ADME/DMPK data, ability to extract preclinical PKPD/efficacy and safety data and translate to human setting to guide therapeutic design and candidate selection, and implementation of effective de-risking plans.
  • Strong problem-solving and leadership skills, highly motivated and self-driven with a keen interest in staying at the forefront of DMPK science and technology.
  • Strong knowledge of relevant regulations and industry standards.

Preferred Skills

  • Prior experience with multiple therapeutic modalities (e.g., small molecules, peptides, biologics, etc).
  • In-depth understanding and experience in discovery bioanalytical science, including immunoassay, LC/MS.
  • In-depth understanding of modeling principles, including noncompartmental analysis. Hands-on experience with modeling using various software packages.
  • Knowledge of novel and translatable in vitro cellular models and/or in vivo models.
  • Strong knowledge of relevant regulations and industry standards, and experience with regulatory submissions are highly desirable.
Director of Chemistry Apply now

Lead peptide chemistry strategy across discovery and early development programs. Read more

location_onDoylestown, PA
timer_5Full time

Job Summary

We are seeking a highly motivated and experienced Director of Chemistry at our Doylestown, PA (on site). The successful candidate will work within the discovery and early development teams and be responsible for leading process chemistry of our peptide programs. The candidate must have demonstrated an ability to work collaboratively in a fast-paced, multidisciplinary, dynamic environment with excellent scientific and communication skills.

Key Responsibilities

  • Serve as a subject matter expert, chemistry project leader in peptide discovery efforts.
  • Oversee SAR campaigns, leading the design, synthesis, and optimization of peptides and peptide conjugates. Work closely with partner functions in chemistry, computational chemistry, molecular and cellular biology, pharmacology, ADME/PK, structural biology, and other key functions.
  • Analyze data, design, propose, and implement discovery plans, coordinate chemistry and biology effects to support project goals.
  • Formulate conclusions and design follow-on experiments based on multidisciplinary data.
  • Supervise and manage synthetic chemistry activities internally and/or at contract research organizations (CROs).
  • Travel: 5-15%.

Qualifications

  • Ph.D. in Synthetic Chemistry, Medicinal Chemistry, or a related discipline with 5+ years of relevant industry experience; orM.S.with 8+ years; orB.S.with 10+ years of experience in peptide or medicinal chemistry.
  • Demonstrated expertise in peptide chemistry, including design, synthesis, and optimization of peptides and peptide conjugates.
  • Strong track record of leading or significantly contributing to discovery-stage programs, including SAR development and advancement of candidates toward preclinical milestones.
  • Experience with solid-phase and/or solution-phase peptide synthesis, as well as modern medicinal chemistry approaches.
  • Familiarity with one or more peptide discovery platforms (e.g., phage display, mRNA display, DEL, or related technologies).
  • Experience applying structure-based design principles to optimize key properties such as potency, stability, permeability, and PK profiles.
  • Hands-on experience with or strong understanding of advanced synthetic strategies (e.g., cyclization, conjugation, late-stage functionalization).
  • Exposure to oral peptide design strategies and/or beyond-Rule-of-5 (bRo5) chemical space is highly desirable.
  • Experience working in cross-functional teams and effectively collaborating with biology, DMPK, computational chemistry, and structural biology partners.
  • Demonstrated ability to manage multiple priorities in a fast-paced, dynamic environment, including oversight of external CROs.
  • Excellent written and verbal communication skills, with the ability to clearly present complex scientific concepts and data.
  • Experience leveraging computational or AI/ML approaches in peptide discovery is a plus.

Ready to help advance the future of therapeutics?

We are growing and continuously seeking outstanding talent. If you do not see an open role that fits your background today, please email hr@pinnaclemedicines.com and share how you could help us build a leading peptide discovery company.

Apply now